Brazilian Journal of Nephrology (Sep 2022)

One-year impact of COVID-19 pandemic on renal replacement therapy and kidney transplantation in a tertiary center in Southern Brazil

  • Pedro do Valle Teichmann,
  • Marina Oliboni Moschetta,
  • Rodrigo Fontanive Franco,
  • Alessandra Rosa Vicari,
  • Gérson Luiz da Silva Nunes,
  • Maria Angela Kalil Nader Lazzaretti,
  • Miriam Gressler Gomes,
  • Silvia Maria Dorigoni,
  • Paulo Roberto Dall’Agnol,
  • Adriana Klafke,
  • Fernando Saldanha Thomé,
  • Fabio Spuldaro,
  • Homero Agra,
  • Rafael de Almeida,
  • Darlan Martins Lara,
  • Andrea Carla Bauer,
  • Cristina Karhol,
  • Roberto Ceratti Manfro

DOI
https://doi.org/10.1590/2175-8239-jbn-2022-0034en

Abstract

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ABSTRACT Introduction: Patients on renal replacement therapy (RRT) and kidney transplant recipients (KTR) present multiple factors that may increase the risk of death from coronavirus disease 2019 (COVID-19). This study aimed to evaluate the incidence and impact of COVID-19 in RRT patients and KTRs. Methods: Between March 2020 and February 2021, we monitored the RRT population of thirteen dialysis facilities that refer patients for transplantation to our center, a tertiary hospital in Southern Brazil. In the same period, we also monitor COVID-19 incidence and mortality in our KTR population. Demographical, clinical, and COVID-19-related information were analyzed. Results: We evaluated 1545 patients in the dialysis centers, of which 267 (17.4%) were infected by COVID-19 and 53 (19.9%) died. Among 275 patients on the kidney transplant waiting list, 63 patients (22.9%) were infected and seven (11.1%) died. COVID-19 was the leading cause of death (29.2%) among patients on the waiting list. Within the population of 1360 KTR, 134 (9.85%) were diagnosed with COVID-19 and 20 (14.9%) died. The number of kidney transplants decreased by 56.7% compared with the same period in the previous twelve months. Conclusion: In the study period, patients on RRT and KTRs presented a high incidence of COVID-19 and high COVID-19-related lethality. The impact on the patients on the transplant waiting list was less pronounced. The lethality rate observed in both cohorts seems to be related to age, comorbidities, and disease severity.

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