Nature Communications (Aug 2018)

Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

  • Masamichi Nagae,
  • Yasuhiko Kizuka,
  • Emiko Mihara,
  • Yu Kitago,
  • Shinya Hanashima,
  • Yukishige Ito,
  • Junichi Takagi,
  • Naoyuki Taniguchi,
  • Yoshiki Yamaguchi

DOI
https://doi.org/10.1038/s41467-018-05931-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into its catalytic mechanism and a basis for GnT-V inhibition.