Journal of Research in Medical Sciences (Aug 2009)

Association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia

  • mir davood omrani,
  • Soroush Bazargani,
  • Morteza bagheri

Journal volume & issue
Vol. 14, no. 4
pp. 217 – 222

Abstract

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<font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><ul><li><div align="left"><strong>BACKGROUND</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman" size="2">A single nucleotide variation within&nbsp; atechol-o-methyl transferase (COMT) gene may alter the COMT enzyme activity level. Polymorphism of Val158Met in the COMT gene has been related to malignancy. In this regard, a study was carried out to find a possible association between the COMT gene polymorphism in patients with sporadic prostate cancer (PCa) and benign prostatic hyperplasia (BPH).</font></font></div></li><font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><li><div align="left"><strong>METHODS</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman" size="2">All types of COMT158 Val/Met polymorphism were carried out using ASO-PCR method in 41 patients with prostate cancer, 193 patients with benign prostatic hyperplasia and 107 healthy male individuals.</font></font></div></li></font></font><font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><li><div align="left"><strong>RESULTS</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman" size="2">The results of this study showed that the frequency of low producer allele A at codon 158 of the&nbsp; OMT gene is significantly different in BPH group compared to normal male control group (OR, 95% CI, p value 1.95: 1.46, 2.44, 0.021, respectively). However no significant difference was noticed when the comparison was made between prostate cancer group and normal male control group and also between BPH and PCa groups.</font></font></div></li></font></font><font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><li><div align="left"><strong>CONCLUSIONS</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman" size="2">Decreased level of catechol-o-methyl transferase gene activity may play a possible role in benign prostatic hyperplasia development but not in prostate cancer. Increased level of COMT gene activity has a protective role against BPH.</font></font></div></li></font></font><font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><li><div align="left"><strong>KEYWORDS</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman" size="2">Prostate Cancer, Benign Prostatic&nbsp; yperplasia, COMT 158Val/Met Polymorphism.</font></font></div></li></font></font></ul></font></font>

Keywords