Exploring the impact of high shear mixing process parameters on the physical characteristics of excipient powder blend by design of experiments

Abstract

Dry-route manufacturing technology development poses challenges to pharmaceutical technology research specialists, relying on active substance characteristics, excipient selection, and parameter optimization. Amongst various technological possibilities high shear mixing generally ensures dosage uniformity and tablet dissolution through influential shear forces, potentially enhancing dry powder blend processability. This study explores the processability of a placebo formulation within the quality by design framework to address some of the aforementioned challenges.

Keywords

• placebo
• design of experiments
• full factorial
• manufacturing technology optimization