Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission
Ping Chou,
Guan-Hsun Wang,
Shu-Wei Hsueh,
Ya-Chin Yang,
Chung-Chin Kuo
Affiliations
Ping Chou
Department of Physiology, National Taiwan University College of Medicine, 1 Jen-Ai Road, 1st Section, Taipei 100, Taiwan
Guan-Hsun Wang
Department of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Department of Medical Education, Chang Gung Memorial Hospital, Linkou Medical Center, Tao-Yuan, Taiwan
Shu-Wei Hsueh
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Ya-Chin Yang
Department of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Tao-Yuan, Taiwan; Corresponding author
Chung-Chin Kuo
Department of Physiology, National Taiwan University College of Medicine, 1 Jen-Ai Road, 1st Section, Taipei 100, Taiwan; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author
Summary: Epileptic seizures constitute a common neurological disease primarily diagnosed by characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or electroencephalograms. With a basolateral amygdala (BLA) kindling model, we found that the dominant frequency of BLA oscillations is in the delta range (1–5 Hz) in both normal and seizure conditions. Multi-unit discharges are increased with higher seizure staging but remain phase-locked to the delta waves in LFPs. Also, the change in synchrony precedes and outlasts the changes in discharging units as well as behavioral seizures. One short train of stimuli readily drives the pyramidal-inhibitory neuronal networks in BLA slices into prolonged reverberating activities, where the burst and interburst intervals may concurrently set a “natural wavelength” for delta frequencies. Seizures thus could be viewed as erroneous temporospatial continuums to normal oscillations in a system with a built-in synchronizing and resonating nature for information relay.
