CELL DEATH AND CELL CYCLE IN THYMUS DURING EXPERIMENTAL BURN DISEASE IN RAT UNDER THE CONDITION OF ITS TREATMENT BE THE INFUSION OF COMBINED HYPEROSMOLAR SOLUTIONS

Abstract

Summary. In the article presents the results of study the cell death and of the kinetics of cell cycle indicators thymus cells of rats during burn disease after thermal bum injury of the skin on the background of treatment with 0,9% solution of NaCl, drugs lactoprotein with sorbitol or HAES-LX 5%. Burn injuryof the skin on the background of treatment with 0,9% solution of NaCl leads to disruption of the cell cycle of the thymus cells is most higle expressed at 1 and 3 day observation. The use lactoprotein with sorbitol or HAES-LX- 5% can significantly improve the performance of the cell cede of the thymus cell and reduce the negative impact of burn injury: lactoprotein with sorbitol affects on DNA synthesis (s-phase), and the drug HAES-LX-5% affects on apoptosis that manifests a decrease in DNA fragmentation (SUB-G0G1).

Keywords

• thymus, cell death, cell cycle, burn disease, dna cytometry, lactoprotein with sorbitol, haes-lx-5%