Alexander Disease

Abstract

Main teaching point: The main differential diagnosis of leukodystrophy associated with macrocephaly consists of Alexander disease, Canavan disease, and megalencephalic leukodystrophy with subcortical cysts. Distinguishing imaging characteristics of Alexander disease are an apicoposterior gradient of white matter involvement and a periventricular T2-hypointense rim.

Keywords

• alexander disease
• leukodystrophy
• canavan disease
• megalencephalic leukoencephalopathy with subcortical cysts
• macrocephaly