Suzuki-Miyaura Reactions Catalyzed by C2-Symmetric Pd-Multi-Dentate N-Heterocyclic Carbene Complexes

Abstract

Suzuki-Miyaura coupling reactions are promoted by Pd complexes ligated with C2-symmetric multi-dentate N-heterocyclic carbenes derived in situ from Pd(OAc)2 and imidazolium salts. Good to excellent yields were obtained for aryl bromides as substrates. Turnover numbers of up to 105 could be achieved with 5 × 10−4 mol% of Pd(OAc)2/1 × 10−3 mol% NHC precatalyst in 24 h.

Keywords

• imidazolium salt
• N-heterocyclic carbene
• palladium
• Suzuki-Miyaura coupling
• catalysis