Nature Communications (Sep 2016)

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

  • Eri Ishikawa,
  • Hidetaka Kosako,
  • Tomoharu Yasuda,
  • Masaki Ohmuraya,
  • Kimi Araki,
  • Tomohiro Kurosaki,
  • Takashi Saito,
  • Sho Yamasaki

DOI
https://doi.org/10.1038/ncomms12756
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.