mBio
(Feb 2021)
A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion
J. Maximilian Fels,
Robert H. Bortz,
Tanwee Alkutkar,
Eva Mittler,
Rohit K. Jangra,
Jennifer S. Spence,
Kartik Chandran
Affiliations
J. Maximilian Fels
ORCiD Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Robert H. Bortz
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Tanwee Alkutkar
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Eva Mittler
ORCiD Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Rohit K. Jangra
ORCiD Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Jennifer S. Spence
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Kartik Chandran
ORCiD Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
DOI
https://doi.org/10.1128/mBio.03616-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
The 2013–2016 outbreak of Ebola virus disease in West Africa demonstrated the potential for previously localized outbreaks to turn into regional, or even global, health emergencies. With over 28,000 cases and 11,000 confirmed deaths, this outbreak was over 50 times as large as any previously recorded.
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