Comparison of single subthreshold micropulse yellow laser and combined with Ranibizumab intravitreal injection for diabetic macular edema

Abstract

AIM: To compare the clinical effects and safety of single subthreshold micropulse(STMP)yellow laser and combined ranibizumab intravitreal injection on the treatment of diabetic macular edema(DME).METHODS: Totally 33 patients(58 eyes)with DME were divided into two groups. Group A(laser group)received STMP yellow laser, and group B(combined treatment group)received ranibizumab intravitreal injection combined with STMP yellow laser. The best corrected visual acuity(BCVA), intraocular pressure(IOP), central macular thickness(CMT), total macular volume(TMV), fluorescein fundus angiography(FFA), multifocal ERG(MERG), autofluorescence(AF)and macular pigment optical density(MPOD)were compared before and after the treatments. And treatment times were counted. RESULTS:Compared with those before treatment, there were significant differences in BCVA and TMV 6, 9, 12mo after treatment in the laser group(PPP1 amplitude of MEG, Max OD and Mean OD before treatment, there were significant differences for the two groups 12mo after treatment(P1 amplitudes between the two groups after 12mo of treatment(PP=0.943).CONCLUSION:Both single STMP laser and combined with intravitreal injection of ranibizumab can effectively reduce macular edema, improve vision and safety in DME patients. And the combined treatment group has faster and better effect.

Keywords

• micropulse laser
• subthreshold
• high density
• diabetic macular edema
• ranibizumab