The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

Priyam Banerjee; Guan-Yu Xiao; Xiaochao Tan; Veronica J. Zheng; Lei Shi; Maria Neus Bota Rabassedas; Hou-fu Guo; Xin Liu; Jiang Yu; Lixia Diao; Jing Wang; William K. Russell; Jason Roszik; Chad J. Creighton; Jonathan M. Kurie

doi:10.1038/s41467-021-26677-y

Nature Communications (Nov 2021)

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

Priyam Banerjee,
Guan-Yu Xiao,
Xiaochao Tan,
Veronica J. Zheng,
Lei Shi,
Maria Neus Bota Rabassedas,
Hou-fu Guo,
Xin Liu,
Jiang Yu,
Lixia Diao,
Jing Wang,
William K. Russell,
Jason Roszik,
Chad J. Creighton,
Jonathan M. Kurie

Affiliations

Priyam Banerjee: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Guan-Yu Xiao: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Xiaochao Tan: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Veronica J. Zheng: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Lei Shi: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Maria Neus Bota Rabassedas: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
Hou-fu Guo: Department of Molecular and Cellular Biochemistry, University of Kentucky
Xin Liu: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Jiang Yu: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Lixia Diao: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
Jing Wang: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
William K. Russell: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Jason Roszik: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
Chad J. Creighton: Department of Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine
Jonathan M. Kurie: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-021-26677-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

The way in which metastatic tumour cells control endocytic vesicular trafficking networks to establish a front-rear polarity axis that facilitates motility remains unclear. Here, the authors show that the EMT activator ZEB1 influences vesicular trafficking dynamics to execute cell polarity change.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal