Nature Communications (Nov 2021)

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

  • Priyam Banerjee,
  • Guan-Yu Xiao,
  • Xiaochao Tan,
  • Veronica J. Zheng,
  • Lei Shi,
  • Maria Neus Bota Rabassedas,
  • Hou-fu Guo,
  • Xin Liu,
  • Jiang Yu,
  • Lixia Diao,
  • Jing Wang,
  • William K. Russell,
  • Jason Roszik,
  • Chad J. Creighton,
  • Jonathan M. Kurie

DOI
https://doi.org/10.1038/s41467-021-26677-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The way in which metastatic tumour cells control endocytic vesicular trafficking networks to establish a front-rear polarity axis that facilitates motility remains unclear. Here, the authors show that the EMT activator ZEB1 influences vesicular trafficking dynamics to execute cell polarity change.