Luminal Conversion and Immunoregulation by Probiotics

Frontiers in Pharmacology. 2015;6 DOI 10.3389/fphar.2015.00269


Journal Homepage

Journal Title: Frontiers in Pharmacology

ISSN: 1663-9812 (Online)

Publisher: Frontiers Media S.A.

LCC Subject Category: Medicine: Therapeutics. Pharmacology

Country of publisher: Switzerland

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML



Bhanu Priya Ganesh (Baylor College of Medicine)

Bhanu Priya Ganesh (Texas Childrens Hospital)

James eVersalovic (Baylor College of Medicine)

James eVersalovic (Texas Childrens Hospital)


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks


Abstract | Full Text

Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may influence host immunity via microbial metabolite-dependent mechanisms. We describe how intestinal microbes including probiotics generate microbial metabolites that modulate mucosal and systemic immunity.