Nature Communications (Dec 2017)
Identification and characterization of two functional variants in the human longevity gene FOXO3
- Friederike Flachsbart,
- Janina Dose,
- Liljana Gentschew,
- Claudia Geismann,
- Amke Caliebe,
- Carolin Knecht,
- Marianne Nygaard,
- Nandini Badarinarayan,
- Abdou ElSharawy,
- Sandra May,
- Anne Luzius,
- Guillermo G. Torres,
- Marlene Jentzsch,
- Michael Forster,
- Robert Häsler,
- Kathrin Pallauf,
- Wolfgang Lieb,
- Céline Derbois,
- Pilar Galan,
- Dmitriy Drichel,
- Alexander Arlt,
- Andreas Till,
- Ben Krause-Kyora,
- Gerald Rimbach,
- Hélène Blanché,
- Jean-François Deleuze,
- Lene Christiansen,
- Kaare Christensen,
- Michael Nothnagel,
- Philip Rosenstiel,
- Stefan Schreiber,
- Andre Franke,
- Susanne Sebens,
- Almut Nebel
Affiliations
- Friederike Flachsbart
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Janina Dose
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Liljana Gentschew
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Claudia Geismann
- Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel
- Amke Caliebe
- Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Carolin Knecht
- Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Marianne Nygaard
- The Danish Aging Research Center, and the Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark
- Nandini Badarinarayan
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Abdou ElSharawy
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Sandra May
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Anne Luzius
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Guillermo G. Torres
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Marlene Jentzsch
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Michael Forster
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Robert Häsler
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Kathrin Pallauf
- Institute of Human Nutrition and Food Science, Kiel University
- Wolfgang Lieb
- Institute of Epidemiology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel, Niemannsweg 11
- Céline Derbois
- Centre National de Recherche en Génomique Humaine CNRGH-CEA
- Pilar Galan
- Université Sorbonne Paris Cité-UREN, Unité de Recherche en Epidémiologie Nutritionnelle, U557 Inserm, U1125 Inra, Cnam, Université Paris 13, CRNH IdF
- Dmitriy Drichel
- Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics, University of Cologne, Weyertal 115b
- Alexander Arlt
- Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel
- Andreas Till
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Ben Krause-Kyora
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Gerald Rimbach
- Institute of Human Nutrition and Food Science, Kiel University
- Hélène Blanché
- Fondation Jean Dausset-Centre d’Etude du Polymorphisme Humain (CEPH), 27 Rue Juliette Dodu
- Jean-François Deleuze
- Centre National de Recherche en Génomique Humaine CNRGH-CEA
- Lene Christiansen
- The Danish Aging Research Center, and the Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark
- Kaare Christensen
- The Danish Aging Research Center, and the Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark
- Michael Nothnagel
- Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics, University of Cologne, Weyertal 115b
- Philip Rosenstiel
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Stefan Schreiber
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- Susanne Sebens
- Institute for Experimental Cancer Research, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3
- Almut Nebel
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Campus Kiel
- DOI
- https://doi.org/10.1038/s41467-017-02183-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.
