Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

Abstract

A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

Keywords

• Quinazolinone
• Phase Transfer Catalyst
• synthesis
• antifungal activity