The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose
Wei-Feng Zhu,
Lin Zhu,
Zhe Li,
Wen-Ting Wu,
Yong-Mei Guan,
Li-Hua Chen,
Zhi-Xuan Mao,
Liang-Shan Ming
Affiliations
Wei-Feng Zhu
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Lin Zhu
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Zhe Li
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Wen-Ting Wu
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Yong-Mei Guan
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Li-Hua Chen
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Zhi-Xuan Mao
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Liang-Shan Ming
Key Laboratory of Preparation of Modern TCM, Ministry of Education, Research Center for Differentiation and Development of TCM Basic Theory, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China
It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 significantly improved the yield of lactose in the spray drying; (iii) the improved powder properties of porous lactose were more conducive to the downstream operating process for the preparation of health functional food or drug; and (iv) the porous lactose significantly improved the dissolution behavior of curcumin. Therefore, the results obtained are beneficial to boosting the development of porous materials.
