Recent Advances in Microfluidics-Based Chromatography—A Mini Review
Bo Bao,
Zhichao Wang,
Dilantha Thushara,
Achini Liyanage,
Sanja Gunawardena,
Zaiyong Yang,
Shuangliang Zhao
Affiliations
Bo Bao
State Key Laboratory of Chemical Engineering and School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
Zhichao Wang
State Key Laboratory of Chemical Engineering and School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
Dilantha Thushara
Department of Chemical and Process Engineering, University of Moratuwa, Moratuwa 10400, Sri Lanka
Achini Liyanage
Department of Chemical and Process Engineering, University of Moratuwa, Moratuwa 10400, Sri Lanka
Sanja Gunawardena
Department of Chemical and Process Engineering, University of Moratuwa, Moratuwa 10400, Sri Lanka
Zaiyong Yang
Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology and School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
Shuangliang Zhao
State Key Laboratory of Chemical Engineering and School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
Microfluidics-based liquid chromatography is based on the miniaturization of the different types of liquid chromatography (LC) systems (e.g., affinity, adsorption, size exclusion, ion exchange) on a microchip to perform on-chip separation of different types of analytes. On-chip chromatography finds applications in genomics, proteomics, biomarker discovery, and environmental analysis. Microfluidics-based chromatography has good reproducibility and small sample consumption. However, the on-chip chromatography fabrication techniques are often more challenging to perform than conventional LC column preparation. Different research groups have attempted to develop different techniques to fabricate microfluidics-based LC systems. In this review, we will summarize the recent advances in microfluidics-based chromatography.
