Nature Communications (Oct 2021)
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses
- Weina Sun,
- Yonghong Liu,
- Fatima Amanat,
- Irene González-Domínguez,
- Stephen McCroskery,
- Stefan Slamanig,
- Lynda Coughlan,
- Victoria Rosado,
- Nicholas Lemus,
- Sonia Jangra,
- Raveen Rathnasinghe,
- Michael Schotsaert,
- Jose L. Martinez,
- Kaori Sano,
- Ignacio Mena,
- Bruce L. Innis,
- Ponthip Wirachwong,
- Duong Huu Thai,
- Ricardo Das Neves Oliveira,
- Rami Scharf,
- Richard Hjorth,
- Rama Raghunandan,
- Florian Krammer,
- Adolfo García-Sastre,
- Peter Palese
Affiliations
- Weina Sun
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Yonghong Liu
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Fatima Amanat
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Irene González-Domínguez
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Stephen McCroskery
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Stefan Slamanig
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Lynda Coughlan
- University of Maryland School of Medicine, Department of Microbiology and Immunology
- Victoria Rosado
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Nicholas Lemus
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Sonia Jangra
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Raveen Rathnasinghe
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Michael Schotsaert
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Jose L. Martinez
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Kaori Sano
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Ignacio Mena
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Bruce L. Innis
- PATH, Center for Vaccine Access and Innovation
- Ponthip Wirachwong
- The Government Pharmaceutical Organization
- Duong Huu Thai
- Institute of Vaccines and Medical Biologicals
- Ricardo Das Neves Oliveira
- Instituto Butantan
- Rami Scharf
- PATH, Center for Vaccine Access and Innovation
- Richard Hjorth
- PATH, Center for Vaccine Access and Innovation
- Rama Raghunandan
- PATH, Center for Vaccine Access and Innovation
- Florian Krammer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Adolfo García-Sastre
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Peter Palese
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-021-26499-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Here the authors show that a Newcastle disease virus based COVID-19 vaccine expressing a stabilized spike protein induces protective immunity in small animal models and reduces replication of variants of concerns. This vaccine candidate can be produced by influenza virus vaccine manufactures around the world.
