Arquivos de Neuro-Psiquiatria (Sep 2024)

Long-COVID olfactory dysfunction: allele E4 of apolipoprotein E as a possible protective factor

  • Danilo Nunes Oliveira,
  • José Wagner Leonel Tavares-Júnior,
  • Werbety Lucas Queiroz Feitosa,
  • Letícia Chaves Vieira Cunha,
  • Carmem Meyve Pereira Gomes,
  • Caroline Aquino Moreira-Nunes,
  • Jean Breno Silveira da Silva,
  • Artur Victor Menezes Sousa,
  • Safira de Brito Gaspar,
  • Emmanuelle Silva Tavares Sobreira,
  • Laís Lacerda Brasil de Oliveira,
  • Raquel Carvalho Montenegro,
  • Maria Elisabete Amaral de Moraes,
  • Manoel Alves Sobreira-Neto,
  • Pedro Braga-Neto

DOI
https://doi.org/10.1055/s-0044-1788272
Journal volume & issue
Vol. 82, no. 09
pp. 001 – 007

Abstract

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Background Olfactory dysfunction (OD) represents a frequent manifestation of the coronavirus disease 2019 (COVID-19). Apolipoprotein E (APOE) is a protein that interacts with the angiotensin-converting enzyme receptor, essential for viral entry into the cell. Previous publications have suggested a possible role of APOE in COVID-19 severity. As far as we know, no publications found significant associations between this disease's severity, OD, and APOE polymorphisms (E2, E3, and E4).

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