Терапевтический архив (Jun 2024)

Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of riamilovir in the treatment of COVID-19

  • Alebai U. Sabitov,
  • Dmitry A. Lioznov,
  • Konstantin V. Zhdanov,
  • Elena P. Tikhonova,
  • Elena V. Esaulenko,
  • Olga P. Kovtun,
  • Pavel L. Kuznetsov,
  • Pavel V. Sorokin

DOI
https://doi.org/10.26442/00403660.2024.05.202770
Journal volume & issue
Vol. 96, no. 5
pp. 517 – 522

Abstract

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Aim. To evaluate the efficacy and safety of riamilovir in the treatment of COVID-19 in adults. Materials and methods. The study included 180 patients with a laboratory-confirmed diagnosis of COVID-19 which fully meet the criteria for inclusion, non-inclusion and exclusion, signed a voluntary informed consent to participate in a clinical trial. Results. The efficacy, good tolerability and safety of the drug riamilovir in the treatment of COVID-19 have been established. Conclusion. As a result of a multicenter randomized double-blind clinical trial, the effectiveness of the drug riamilovir for therapeutic use in patients with COVID-19 according to the 1250 mg/day scheme (250 mg capsules 5 times per day) for 10 days was established. The drug riamilovir in a daily dose of 1250 mg for 10 days does not differ in safety from placebo.

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