Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Dae-Sun Kim; Himika Dastidar; Chunfen Zhang; Franz J. Zemp; Keith Lau; Matthias Ernst; Andrea Rakic; Saif Sikdar; Jahanara Rajwani; Victor Naumenko; Dale R. Balce; Ben W. Ewanchuk; Pankaj Tailor; Robin M. Yates; Craig Jenne; Chris Gafuik; Douglas J. Mahoney

doi:10.1038/s41467-017-00324-x

Nature Communications (Aug 2017)

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Dae-Sun Kim,
Himika Dastidar,
Chunfen Zhang,
Franz J. Zemp,
Keith Lau,
Matthias Ernst,
Andrea Rakic,
Saif Sikdar,
Jahanara Rajwani,
Victor Naumenko,
Dale R. Balce,
Ben W. Ewanchuk,
Pankaj Tailor,
Robin M. Yates,
Craig Jenne,
Chris Gafuik,
Douglas J. Mahoney

Affiliations

Dae-Sun Kim: Alberta Children’s Hospital Research Institute
Himika Dastidar: Alberta Children’s Hospital Research Institute
Chunfen Zhang: Alberta Children’s Hospital Research Institute
Franz J. Zemp: Alberta Children’s Hospital Research Institute
Keith Lau: Alberta Children’s Hospital Research Institute
Matthias Ernst: Alberta Children’s Hospital Research Institute
Andrea Rakic: Alberta Children’s Hospital Research Institute
Saif Sikdar: Alberta Children’s Hospital Research Institute
Jahanara Rajwani: Alberta Children’s Hospital Research Institute
Victor Naumenko: Alberta Children’s Hospital Research Institute
Dale R. Balce: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary
Ben W. Ewanchuk: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary
Pankaj Tailor: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary
Robin M. Yates: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary
Craig Jenne: Department of Microbiology, Immunology and Infectious Disease, Faculty of Medicine, University of Calgary
Chris Gafuik: Alberta Children’s Hospital Research Institute
Douglas J. Mahoney: Alberta Children’s Hospital Research Institute

DOI: https://doi.org/10.1038/s41467-017-00324-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal