Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

Keywords

• cisd2
• nonalcoholic fatty liver disease
• hepatocellular carcinoma
• haploinsufficiency
• tumor suppressor gene
• er stress
• calcium homeostasis
• serca2b