Nature Communications (Nov 2016)
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
Abstract
Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.