Nature Communications (Nov 2016)

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

  • Melissa F. Brereton,
  • Maria Rohm,
  • Kenju Shimomura,
  • Christian Holland,
  • Sharona Tornovsky-Babeay,
  • Daniela Dadon,
  • Michaela Iberl,
  • Margarita V. Chibalina,
  • Sheena Lee,
  • Benjamin Glaser,
  • Yuval Dor,
  • Patrik Rorsman,
  • Anne Clark,
  • Frances M. Ashcroft

DOI
https://doi.org/10.1038/ncomms13496
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.