MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

Sen Liu; Min Fan; Qiang Zheng; Shengwei Hao; Longjun Yang; Qingrong Xia; Congcong Qi; Jinfang Ge

Biomedicine & Pharmacotherapy (Apr 2022)

MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

Sen Liu,
Min Fan,
Qiang Zheng,
Shengwei Hao,
Longjun Yang,
Qingrong Xia,
Congcong Qi,
Jinfang Ge

Affiliations

Sen Liu: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China
Min Fan: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China
Qiang Zheng: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China
Shengwei Hao: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China
Longjun Yang: Chaohu Clinical Medical College, Anhui Medical University, Hefei, China
Qingrong Xia: Department of Pharmacy, Hefei Fourth People's Hospital, Hefei, China
Congcong Qi: Department of Laboratory Animal Science, Fudan University, Shanghai, China; Correspondence to: Department of Laboratory Animal Science, Fudan University, 130 Dong-An Road, Shanghai 200032, China.
Jinfang Ge: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, Hefei, China; Correspondence to: School of Pharmacy, Anhui Medical University, 81 Mei-Shan Road, Hefei, Anhui 230032, China.

Journal volume & issue: Vol. 148
p. 112681

Abstract

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Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive decline as the primary clinical feature. According to epidemiological statistics, 50 million people worldwide are currently affected by Alzheimer's disease. Although new drugs such as aducanumab have been approved for use in the treatment of AD, none of them have reversed the progression of AD. MicroRNAs (miRNAs) are small molecule RNAs that exert their biological functions by regulating the expression of intracellular proteins, and differential abundance and varieties are found between the central and peripheral tissues of AD patients and healthy controls. This article will summarise the changes of miRNAs in the AD process, and the potential role of diagnostic markers and therapeutic targets in AD will be explored.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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Abstract

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