Molecules (Feb 2024)

Discovery of a New Compound, Erinacerin W, from the Mycelia of <i>Hericium erinaceus</i>, with Immunomodulatory and Neuroprotective Effects

  • Jing-Yi Lin,
  • Yen-Po Chen,
  • Ting-Wei Lin,
  • Tsung-Ju Li,
  • Yu-Wen Chen,
  • I-Chen Li,
  • Chin-Chu Chen

DOI
https://doi.org/10.3390/molecules29040812
Journal volume & issue
Vol. 29, no. 4
p. 812

Abstract

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One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine. Based on analysis of MS and NMR spectral data, the structure of the compound was identified as (2E,6E)-8-(2-(1-carboxy-3-methylbutyl)-4,6-dihydroxy-1-oxoisoindolin-5-yl)-2,6-dimethylocta-2,6-dienoic acid. In light of this discovery, we have given this compound the name erinacerin W. Using a co-culture in vitro LPS-activated BV2 microglia-induced SH-SY5Y neuroinflammation model, the results showed that erinacerin W demonstrated protection against the LPS-activated BV-2 cell-induced overexpression of IL-6, IL-1β, and TNF-α on SH-SY5Y cells. This finding may provide potential therapeutic approaches for central nervous disorders.

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