Nature Communications (Jan 2020)
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
- Katharina von Loga,
- Andrew Woolston,
- Marco Punta,
- Louise J. Barber,
- Beatrice Griffiths,
- Maria Semiannikova,
- Georgia Spain,
- Benjamin Challoner,
- Kerry Fenwick,
- Ronald Simon,
- Andreas Marx,
- Guido Sauter,
- Stefano Lise,
- Nik Matthews,
- Marco Gerlinger
Affiliations
- Katharina von Loga
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Andrew Woolston
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Marco Punta
- Bioinformatics Core, Centre for Evolution and Cancer, The Institute of Cancer Research
- Louise J. Barber
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Beatrice Griffiths
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Maria Semiannikova
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Georgia Spain
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Benjamin Challoner
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- Kerry Fenwick
- Tumour Profiling Unit, The Institute of Cancer Research
- Ronald Simon
- Institute of Pathology, University Medical Center Hamburg-Eppendorf
- Andreas Marx
- Institute of Pathology, University Medical Center Hamburg-Eppendorf
- Guido Sauter
- Institute of Pathology, University Medical Center Hamburg-Eppendorf
- Stefano Lise
- Bioinformatics Core, Centre for Evolution and Cancer, The Institute of Cancer Research
- Nik Matthews
- Tumour Profiling Unit, The Institute of Cancer Research
- Marco Gerlinger
- Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-019-13915-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.
