Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Qi Shang; Wandong Liu; Faith Leslie; Jiapei Yang; Mingmei Guo; Mingjiao Sun; Guangji Zhang; Qiang Zhang; Feihu Wang

Acta Pharmaceutica Sinica B (Apr 2024)

Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Qi Shang,
Wandong Liu,
Faith Leslie,
Jiapei Yang,
Mingmei Guo,
Mingjiao Sun,
Guangji Zhang,
Qiang Zhang,
Feihu Wang

Affiliations

Qi Shang: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Wandong Liu: School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, Hangzhou 310053, China
Faith Leslie: Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, the Johns Hopkins University, Baltimore, MD 21218, USA
Jiapei Yang: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Mingmei Guo: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Mingjiao Sun: Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, the Johns Hopkins University, Baltimore, MD 21218, USA
Guangji Zhang: School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, Hangzhou 310053, China; Traditional Chinese Medicine “Preventing Disease” Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China; Corresponding authors.
Qiang Zhang: Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; Corresponding authors.
Feihu Wang: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authors.

Journal volume & issue: Vol. 14, no. 4
pp. 1525 – 1541

Abstract

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Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b

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