Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation

Wanida Ono; Naoko Sakagami; Shigeki Nishimori; Noriaki Ono; Henry M. Kronenberg

doi:10.1038/ncomms11277

Nature Communications (Apr 2016)

Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation

Wanida Ono,
Naoko Sakagami,
Shigeki Nishimori,
Noriaki Ono,
Henry M. Kronenberg

Affiliations

Wanida Ono: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School
Naoko Sakagami: Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry
Shigeki Nishimori: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School
Noriaki Ono: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School
Henry M. Kronenberg: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/ncomms11277
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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How the parathyroid hormone-related protein receptor (PPR) and its ligand act in root formation and tooth eruption is unclear. Here, the authors identify osterix-expressing dental mesenchymal cells as progenitors for root formation and that PPR signalling mediates their differentiation and tooth eruption.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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