Nature Communications (Mar 2018)
Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer
- Sara Bobisse,
- Raphael Genolet,
- Annalisa Roberti,
- Janos L. Tanyi,
- Julien Racle,
- Brian J. Stevenson,
- Christian Iseli,
- Alexandra Michel,
- Marie-Aude Le Bitoux,
- Philippe Guillaume,
- Julien Schmidt,
- Valentina Bianchi,
- Denarda Dangaj,
- Craig Fenwick,
- Laurent Derré,
- Ioannis Xenarios,
- Olivier Michielin,
- Pedro Romero,
- Dimitri S. Monos,
- Vincent Zoete,
- David Gfeller,
- Lana E. Kandalaft,
- George Coukos,
- Alexandre Harari
Affiliations
- Sara Bobisse
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Raphael Genolet
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Annalisa Roberti
- Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
- Janos L. Tanyi
- Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
- Julien Racle
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Brian J. Stevenson
- Swiss Institute of Bioinformatics
- Christian Iseli
- Swiss Institute of Bioinformatics
- Alexandra Michel
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Marie-Aude Le Bitoux
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Philippe Guillaume
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Julien Schmidt
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Valentina Bianchi
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Denarda Dangaj
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Craig Fenwick
- Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital
- Laurent Derré
- Urology Research Unit, Lausanne University Hospital
- Ioannis Xenarios
- Swiss Institute of Bioinformatics
- Olivier Michielin
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Pedro Romero
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Dimitri S. Monos
- Department of Pathology and Laboratory Medicine, Immunogenetics Laboratory, The Children’s Hospital of Philadelphia
- Vincent Zoete
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- David Gfeller
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Lana E. Kandalaft
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- George Coukos
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- Alexandre Harari
- Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-018-03301-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity in TILs.
