Communications Biology (Oct 2022)

Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

  • Marco S. Kaiser,
  • Giulia Milan,
  • Daniel J. Ham,
  • Shuo Lin,
  • Filippo Oliveri,
  • Kathrin Chojnowska,
  • Lionel A. Tintignac,
  • Nitish Mittal,
  • Christian E. Zimmerli,
  • David J. Glass,
  • Mihaela Zavolan,
  • Markus A. Rüegg

DOI
https://doi.org/10.1038/s42003-022-04097-y
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 18

Abstract

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Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.