Nature Communications (Apr 2018)

Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

  • Yumeng Liu,
  • Melissa M. Budelier,
  • Katelyn Stine,
  • Martin St. Maurice

DOI
https://doi.org/10.1038/s41467-018-03814-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate carboxylase and suggest a basis for its allosteric activation.