New advances in immune mechanism and treatment during ocular toxoplasmosis

Zijian Chen; Shizhou Cheng; Xiaoming Chen; Zuhai Zhang; Yanhua Du

doi:10.3389/fimmu.2024.1403025

Frontiers in Immunology (May 2024)

New advances in immune mechanism and treatment during ocular toxoplasmosis

Zijian Chen,
Shizhou Cheng,
Xiaoming Chen,
Zuhai Zhang,
Yanhua Du

Affiliations

Zijian Chen: Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China
Shizhou Cheng: Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China
Xiaoming Chen: Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China
Zuhai Zhang: Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China
Yanhua Du: Physical Examination Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China

DOI: https://doi.org/10.3389/fimmu.2024.1403025
Journal volume & issue: Vol. 15

Abstract

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Ocular toxoplasmosis (OT) is an intraocular infection caused by the parasite Toxoplasma gondii. OT is manifested as retinal choroiditis and is the most common infectious cause of posterior uveitis. Invasion of the retina by T. gondii leads to disruption of the blood-ocular barrier and promotes the migration of immune cells to the ocular tissues. Cytokines such as IFN-γ and IL-1β are effective for controlling parasite growth, but excessive inflammatory responses can cause damage to the host. In this review, we will discuss in detail the latest advances in the immunopathology and treatment of OT.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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