Exposure of Human Endothelial Progenitors to Sevoflurane Improves Their Survival Abilities

Abstract

Endothelial progenitor cells (EPCs) have prominent roles in vessel and tissue repair; however, their regenerative efficacy is diminished due to the poor survival in the hostile microenvironment of the injured organs. Recent data suggest a promising potential of volatile anesthetics for improving stem cell biology. Thus, we hypothesized that exposure to sevoflurane could stimulate growth and viability of cultured EPCs.

Keywords

• priming
• sevoflurane
• progenitor cells
• apoptosis
• proliferation