Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs

Abstract

The thalidomide disaster, in the 60,s, is the most painful reminder of the importance of chirality for biological activity. After this episode, much attention has been devoted to study the correlations between toxicological and pharmacological properties and chirality. Actualy, to get a licence for a new chiral drug in EUA, European community and Japan, it is necessary to study the biological properties of each enatiomer independently. This article presents an overview about the importance of the chirality of organic compounds and its relationships with biological activity, asymmetric synthetic methodologies and market.

Keywords

• chiral technology
• asymmetric synthesis
• drugs chirality