Structural basis for the target specificity of actin histidine methyltransferase SETD3

Shaobo Dai; John R. Horton; Clayton B. Woodcock; Alex W. Wilkinson; Xing Zhang; Or Gozani; Xiaodong Cheng

doi:10.1038/s41467-019-11554-6

Nature Communications (Aug 2019)

Structural basis for the target specificity of actin histidine methyltransferase SETD3

Shaobo Dai,
John R. Horton,
Clayton B. Woodcock,
Alex W. Wilkinson,
Xing Zhang,
Or Gozani,
Xiaodong Cheng

Affiliations

Shaobo Dai: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
John R. Horton: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Clayton B. Woodcock: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Alex W. Wilkinson: Department of Biology, Stanford University
Xing Zhang: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Or Gozani: Department of Biology, Stanford University
Xiaodong Cheng: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-019-11554-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

Read online

SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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