Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

Hao Shu; Lihua Gu; Ping Yang; Molly V. Lucas; Lijuan Gao; Hongxing Zhang; Haisan Zhang; Zhan Xu; Wei Wu; Ling Li; Zhijun Zhang

NeuroImage: Clinical (Jan 2021)

Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

Hao Shu,
Lihua Gu,
Ping Yang,
Molly V. Lucas,
Lijuan Gao,
Hongxing Zhang,
Haisan Zhang,
Zhan Xu,
Wei Wu,
Ling Li,
Zhijun Zhang

Affiliations

Hao Shu: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China
Lihua Gu: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China
Ping Yang: Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Molly V. Lucas: Department of Psychiatry and Behavioral Sciences and Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, CA 94394, USA
Lijuan Gao: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China
Hongxing Zhang: Department of Psychiatry, The Second Affiliated Hospital of Xingxiang Medical University, Xinxiang, Henan 453002, China
Haisan Zhang: Department of Psychiatry, The Second Affiliated Hospital of Xingxiang Medical University, Xinxiang, Henan 453002, China
Zhan Xu: Imaging Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Wei Wu: School of Automation Science and Engineering, South China University of Technology, Guangzhou 510640, China; Department of Psychiatry and Behavioral Sciences and Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, CA 94394, USA; Corresponding authors at: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China (Z. Zhang). Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (L. Li). School of Automation Science and Engineering, South China University of Technology, Guangzhou 510640, China (W. Wu).
Ling Li: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China; Corresponding authors at: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China (Z. Zhang). Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (L. Li). School of Automation Science and Engineering, South China University of Technology, Guangzhou 510640, China (W. Wu).
Zhijun Zhang: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China; Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Psychiatry, The Second Affiliated Hospital of Xingxiang Medical University, Xinxiang, Henan 453002, China; Corresponding authors at: Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Neuropsychiatric Institute, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210009, China (Z. Zhang). Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China (L. Li). School of Automation Science and Engineering, South China University of Technology, Guangzhou 510640, China (W. Wu).

Journal volume & issue: Vol. 30
p. 102572

Abstract

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Episodic memory (EM) deficit is the core cognitive dysfunction of amnestic mild cognitive impairment (aMCI). However, the episodic retrieval pattern detected by functional MRI (fMRI) appears preserved in aMCI subjects. To address this discrepancy, simultaneous electroencephalography (EEG)-fMRI recording was employed to determine whether temporal dynamics of brain episodic retrieval activity were disturbed in patients with aMCI. Twenty-six aMCI and 29 healthy control (HC) subjects completed a word-list memory retrieval task during simultaneous EEG-fMRI. The retrieval success activation pattern was detected with fMRI analysis, and the familiarity- and recollection-related components of episodic retrieval activity were identified using event-related potential (ERP) analysis. The fMRI-constrained ERP analysis explored the temporal dynamics of brain activity in the retrieval success pattern, and the ERP-informed fMRI analysis detected fMRI correlates of the ERP components related to familiarity and recollection processes. The two groups exhibited similar retrieval success patterns in the bilateral posteromedial parietal cortex, the left inferior parietal lobule (IPL), and the left lateral prefrontal cortex (LPFC). The fMRI-constrained ERP analysis showed that the aMCI group did not exhibit old/new effects in the IPL and LPFC that were observed in the HC group. In addition, the aMCI group showed disturbed fMRI correlate of ERP recollection component that was associated with inferior EM performance. Therefore, in this study, we identified disturbed temporal dynamics in episodic retrieval activity with a preserved spatial activity pattern in aMCI. Taken together, the simultaneous EEG-fMRI technique demonstrated the potential to identify individuals with a high risk of cognitive deterioration.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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