Genetics and Molecular Biology (Sep 2024)

Pioneering role of RNA in the early evolution of life

  • Israel Muñoz-Velasco,
  • Adrián Cruz-González,
  • Ricardo Hernández-Morales,
  • José Alberto Campillo-Balderas,
  • Wolfgang Cottom-Salas,
  • Rodrigo Jácome,
  • Alberto Vázquez-Salazar

DOI
https://doi.org/10.1590/1678-4685-gmb-2024-0028
Journal volume & issue
Vol. 47, no. suppl 1

Abstract

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Abstract The catalytic, regulatory and structural properties of RNA, combined with their extraordinary ubiquity in cellular processes, are consistent with the proposal that this molecule played a much more conspicuous role in heredity and metabolism during the early stages of biological evolution. This review explores the pivotal role of RNA in the earliest life forms and its relevance in modern biological systems. It examines current models that study the early evolution of life, providing insights into the primordial RNA world and its legacy in contemporary biology.

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