Nature Communications (Apr 2022)
Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer
- Tsion Zewdu Minas,
- Julián Candia,
- Tiffany H. Dorsey,
- Francine Baker,
- Wei Tang,
- Maeve Kiely,
- Cheryl J. Smith,
- Amy L. Zhang,
- Symone V. Jordan,
- Obadi M. Obadi,
- Anuoluwapo Ajao,
- Yao Tettey,
- Richard B. Biritwum,
- Andrew A. Adjei,
- James E. Mensah,
- Robert N. Hoover,
- Frank J. Jenkins,
- Rick Kittles,
- Ann W. Hsing,
- Xin W. Wang,
- Christopher A. Loffredo,
- Clayton Yates,
- Michael B. Cook,
- Stefan Ambs
Affiliations
- Tsion Zewdu Minas
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Julián Candia
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Tiffany H. Dorsey
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Francine Baker
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Wei Tang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Maeve Kiely
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Cheryl J. Smith
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Amy L. Zhang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Symone V. Jordan
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Obadi M. Obadi
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Anuoluwapo Ajao
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yao Tettey
- University of Ghana Medical School
- Richard B. Biritwum
- University of Ghana Medical School
- Andrew A. Adjei
- University of Ghana Medical School
- James E. Mensah
- University of Ghana Medical School
- Robert N. Hoover
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health
- Frank J. Jenkins
- Hillman Cancer Center, University of Pittsburgh
- Rick Kittles
- Division of Health Equities, Department of Population Sciences, City of Hope Comprehensive Cancer Center
- Ann W. Hsing
- Stanford Cancer Institute, Stanford School of Medicine
- Xin W. Wang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Christopher A. Loffredo
- Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Clayton Yates
- Department of Biology and Center for Cancer Research, Tuskegee University
- Michael B. Cook
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health
- Stefan Ambs
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-29235-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here the authors report that systemic cytokines linked to suppression of tumor immunity are upregulated in men of African ancestry and associated with reduced survival.
