Nature Communications (Apr 2019)

Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

  • Zhibin Liu,
  • Haiqing Tu,
  • Yunsi Kang,
  • Yuanyuan Xue,
  • Dongyuan Ma,
  • Chengtian Zhao,
  • Huiyan Li,
  • Lu Wang,
  • Feng Liu

DOI
https://doi.org/10.1038/s41467-019-09403-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.