Креативная хирургия и онкология (Jan 2017)

NEOLYMPHOGENESIS AND CHEMOKINES’EXPRESSION PROFILE DURING BREAST CANCER

  • Sh. Kh. Gantsev,
  • A. G. Pukhov,
  • E. K. Khusnutdinova,
  • M. G. Galeyev,
  • K. Sh. Gantsev,
  • R. Sh. Ishmuratova,
  • D. V. Islamgulov,
  • B. Yu. Frolova,
  • Sh. R. Kzyrgalin,
  • Sh. I. Musin,
  • L. V. Khalikova

DOI
https://doi.org/10.24060/2076-3093-2012-0-1-4-9
Journal volume & issue
Vol. 0, no. 1
pp. 4 – 9

Abstract

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The research of surgical material including a primary breast tumor, lymphatic basins with lymph nodes revealed the fact of neo-lymphatic genesis of breast cancer patients. Evidentiary basis of the genetic lymphoid re-forming is made with the use of modern biological technologies. Inflammatory chemokines’ expression profile and their receptors in newly formed lymph nodes during breast cancer were analyzed. The analysis revealed an increase in CCL16, XCR1, CYFIP2, TNFSF14 genes and a decrease in CXCL5 and CXCL12 chemokines’ ligands in newly formed lymph nodes .The data got are of a great scientific importance.

Keywords