Nature Communications (May 2017)

Structural basis for perception of diverse chemical substances by T1r taste receptors

  • Nipawan Nuemket,
  • Norihisa Yasui,
  • Yuko Kusakabe,
  • Yukiyo Nomura,
  • Nanako Atsumi,
  • Shuji Akiyama,
  • Eriko Nango,
  • Yukinari Kato,
  • Mika K. Kaneko,
  • Junichi Takagi,
  • Maiko Hosotani,
  • Atsuko Yamashita

DOI
https://doi.org/10.1038/ncomms15530
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Nutrients taste perception is mediated by T1r receptors that discriminate specific tastes among their wide diversity. Here the authors present crystal structures of the ligand-binding domains of the fish T1r2-T1r3 receptor, providing a structural framework for its ligand recognition.