Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
Albert Granados,
Pau Sarró,
Adelina Vallribera
Affiliations
Albert Granados
Department of Chemistry, Universitat Autònoma de Barcelona and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Cerdanyola del Vallès, 08193 Barcelona, Spain
Pau Sarró
Department of Chemistry, Universitat Autònoma de Barcelona and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Cerdanyola del Vallès, 08193 Barcelona, Spain
Adelina Vallribera
Department of Chemistry, Universitat Autònoma de Barcelona and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Cerdanyola del Vallès, 08193 Barcelona, Spain
A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
