Nature Communications (Jul 2020)

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

  • Maria-Patapia Zafeiriou,
  • Guobin Bao,
  • James Hudson,
  • Rashi Halder,
  • Alica Blenkle,
  • Marie-Kristin Schreiber,
  • Andre Fischer,
  • Detlev Schild,
  • Wolfram-Hubertus Zimmermann

DOI
https://doi.org/10.1038/s41467-020-17521-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.