Frontiers in Oncology (May 2021)
Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins
- Defa Huang,
- Defa Huang,
- Jie Chen,
- Jie Chen,
- Die Hu,
- Die Hu,
- Fangfang Xie,
- Fangfang Xie,
- Tong Yang,
- Tong Yang,
- Zhengzhe Li,
- Zhengzhe Li,
- Xiaoxing Wang,
- Xiaoxing Wang,
- Yongwei Xiao,
- Yongwei Xiao,
- Jianing Zhong,
- Yu Jiang,
- Xiaokang Zhang,
- Xiaokang Zhang,
- Tianyu Zhong,
- Tianyu Zhong,
- Tianyu Zhong,
- Tianyu Zhong
Affiliations
- Defa Huang
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Defa Huang
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Jie Chen
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Jie Chen
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Die Hu
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Die Hu
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Fangfang Xie
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Fangfang Xie
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Tong Yang
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Tong Yang
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Zhengzhe Li
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Zhengzhe Li
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Xiaoxing Wang
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Xiaoxing Wang
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Yongwei Xiao
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Yongwei Xiao
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Jianing Zhong
- Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China
- Yu Jiang
- Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
- Xiaokang Zhang
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Xiaokang Zhang
- Department of Preventive Medicine, Gannan Medical University, Ganzhou, China
- Tianyu Zhong
- The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China
- Tianyu Zhong
- Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Tianyu Zhong
- Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China
- Tianyu Zhong
- Precision Medicine Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- DOI
- https://doi.org/10.3389/fonc.2021.675940
- Journal volume & issue
-
Vol. 11
Abstract
Small extracellular vesicles are membrane-bound vesicles secreted into extracellular spaces by virtually all types of cells. These carry a large number of membrane proteins on their surface that are incorporated during their biogenesis in cells. The composition of the membrane proteins hence bears the signature of the cells from which they originate. Recent studies have suggested that the proteins on these small extracellular vesicles can serve as biomarkers and target proteins for the diagnosis and treatment of diseases. This article classifies small extracellular vesicle membrane proteins and summarizes their pathophysiological functions in the diagnosis and treatment of diseases.
Keywords
