Communications Biology (May 2022)

TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes

  • Cuilan Hou,
  • Xunwei Jiang,
  • Han Zhang,
  • Junmin Zheng,
  • Qingzhu Qiu,
  • Yongwei Zhang,
  • Xiaomin Sun,
  • Meng Xu,
  • Alex Chia Yu Chang,
  • Lijian Xie,
  • Tingting Xiao

DOI
https://doi.org/10.1038/s42003-022-03414-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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The endoplasmic reticulum protein TECRL promotes mitochondrial function in cardiomyocytes and its knockout in mice leads to cardiac dysfunction, decreased mitochondria function, and elevated levels of reactive oxygen species.