After more than forty years since the 1980 Irpinia-Lucania earthquake, with this Special Issue “The 23 November 1980 Irpinia-Lucania, Southern Italy Earthquake: Insights and Reviews 40 Years Later” we revisit this milestone geological and seismological event, bringing together the latest views and news on this earthquake, with the aim of improving the dissemination of wide-ranging information on this remarkable case history [...]