Molbank (Oct 2020)

2-Propyl-<em>N</em>′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide

  • Mariia Nesterkina,
  • Dmytro Barbalat,
  • Ildar Rakipov,
  • Iryna Kravchenko

DOI
https://doi.org/10.3390/m1164
Journal volume & issue
Vol. 2020, no. 4
p. M1164

Abstract

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2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.

Keywords