Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin

Mingxiong Tan; Jinchan Zhu; Yingming Pan; Zhenfeng Chen; Hong Liang; Huagang Liu; Hengshan Wang

doi:10.1155/2009/347872

Bioinorganic Chemistry and Applications (Jan 2009)

Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin

Mingxiong Tan,
Jinchan Zhu,
Yingming Pan,
Zhenfeng Chen,
Hong Liang,
Huagang Liu,
Hengshan Wang

Affiliations

Mingxiong Tan: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China
Jinchan Zhu: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China
Yingming Pan: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China
Zhenfeng Chen: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China
Hong Liang: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China
Huagang Liu: Department of Pharmacology, Guangxi Medical University, Nanning 530021, China
Hengshan Wang: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China

DOI: https://doi.org/10.1155/2009/347872
Journal volume & issue: Vol. 2009

Abstract

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Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL2(H2O)2]⋅nH2O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.

Published in Bioinorganic Chemistry and Applications

ISSN: 1565-3633 (Print); 1687-479X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Chemistry: Inorganic chemistry
Website: https://onlinelibrary.wiley.com/journal/4036

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