Nature Communications (Oct 2018)

Biosynthetic energy cost for amino acids decreases in cancer evolution

  • Hong Zhang,
  • Yirong Wang,
  • Jun Li,
  • Han Chen,
  • Xionglei He,
  • Huiwen Zhang,
  • Han Liang,
  • Jian Lu

DOI
https://doi.org/10.1038/s41467-018-06461-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Proliferating cancer cells have a high demand for amino acids. Here, Zhang et al. show that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and demonstrate the potential prognostic utility of quantifying the extent of this adaptation.