Nature Communications (Jan 2019)

An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos

  • Longqi Liu,
  • Lizhi Leng,
  • Chuanyu Liu,
  • Changfu Lu,
  • Yue Yuan,
  • Liang Wu,
  • Fei Gong,
  • Shuoping Zhang,
  • Xiaoyu Wei,
  • Mingyue Wang,
  • Lei Zhao,
  • Liang Hu,
  • Jian Wang,
  • Huanming Yang,
  • Shida Zhu,
  • Fang Chen,
  • Guangxiu Lu,
  • Zhouchun Shang,
  • Ge Lin

DOI
https://doi.org/10.1038/s41467-018-08244-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.