Nature Communications (Jan 2019)
An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
- Longqi Liu,
- Lizhi Leng,
- Chuanyu Liu,
- Changfu Lu,
- Yue Yuan,
- Liang Wu,
- Fei Gong,
- Shuoping Zhang,
- Xiaoyu Wei,
- Mingyue Wang,
- Lei Zhao,
- Liang Hu,
- Jian Wang,
- Huanming Yang,
- Shida Zhu,
- Fang Chen,
- Guangxiu Lu,
- Zhouchun Shang,
- Ge Lin
Affiliations
- Longqi Liu
- BGI-Shenzhen
- Lizhi Leng
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Chuanyu Liu
- BGI-Shenzhen
- Changfu Lu
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Yue Yuan
- BGI-Shenzhen
- Liang Wu
- BGI-Shenzhen
- Fei Gong
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Shuoping Zhang
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Xiaoyu Wei
- BGI-Shenzhen
- Mingyue Wang
- BGI-Shenzhen
- Lei Zhao
- Reproductive & Genetic Hospital of CITIC-Xiangya
- Liang Hu
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Jian Wang
- BGI-Shenzhen
- Huanming Yang
- BGI-Shenzhen
- Shida Zhu
- BGI-Shenzhen
- Fang Chen
- BGI-Shenzhen
- Guangxiu Lu
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- Zhouchun Shang
- BGI-Shenzhen
- Ge Lin
- Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University
- DOI
- https://doi.org/10.1038/s41467-018-08244-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.
